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Cefozopran hydrochloride

CAS No. 113981-44-5

Cefozopran hydrochloride( SCE-2787 hydrochloride )

Catalog No. M21205 CAS No. 113981-44-5

Cefozopran hydrochloride is a fourth-generation cephalosporin.?is a cell wall biosynthesis inhibitor with a broad spectrum of activity against Gram-positive and Gram-negative bacteria.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Cefozopran hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Cefozopran hydrochloride is a fourth-generation cephalosporin.?is a cell wall biosynthesis inhibitor with a broad spectrum of activity against Gram-positive and Gram-negative bacteria.
  • Description
    Cefozopran hydrochloride is a fourth-generation cephalosporin.?is a cell wall biosynthesis inhibitor with a broad spectrum of activity against Gram-positive and Gram-negative bacteria.
  • In Vitro
    Cefozopran (SCE-2787) is a fourth-generation cephalosporin that has good activity against gram-positive organisms including methicillin-susceptible staphylococci, enterococci, and viridans group streptococci; and against gram-negative organisms including hemophilus influenza. Moreover, cefozopran has comparatively good activity against enterococci and P. aeruginosa, which are refractory to other cephalosporins.
  • In Vivo
    Cefozopran (SCE-2787) (5-80 mg/kg; s.c.; twice a day for 5 days; four-week-old ICR male mice) is effective against acute respiratory tract infections caused by Kiebsiella pneumonia DT-S. In the model of chronic respiratory tract infection caused by K. pneumoniae 27, Cefozopran (20-80 mg/kg; s.c.; twice a day for 7 days; five-week-old CBA/J female mice) is as effective as Ceftazidime.
  • Synonyms
    SCE-2787 hydrochloride
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Bacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    113981-44-5
  • Formula Weight
    551.99
  • Molecular Formula
    C19H18ClN9O5S2
  • Purity
    >98% (HPLC)
  • Solubility
    H2O:52 mg/mL (94.20 mM)
  • SMILES
    CO/N=C(\C1=NSC(=N1)N)/C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C[N+]4=C5C=CC=NN5C=C4)C(=O)[O-].Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wu G L Shentu J Z Zhou H L et al. Pharmacokinetics of Cefozopran by Single and Multiple Intravenous Infusions in Healthy Chinese Volunteers[J]. Drugs in R & D 2015 15(1):63-70.
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